[Studies on the biosynthesis of testicular androgens].

Direct inhibition of rat testicular androgen biosynthesis by arginine vasotocin. Studies on mechanisms of action.

Studies in steroid metabolism. VIII. Steroidogenesis in a heterologous tumor transplant.

Relatively little is known concerning the main tenance of biochemical integrity of tissue after it has been heterologously transplanted. The pos sibility of tissue enzyme adaptation to the new host following such a transplant is not easily ruled out. This subject is of particular interest in view of the use of human tumor transplants in rodents as a screening method for antitumor agents. A rece...

آندروژن‌ها و عملکرد جنسی در یائسگی

    During menopause , various physical, psychological, social, economic, and cultural factors can affect the sexual function of post-menopausal women. Among the most important of these factors are hormonal conditions . The present study is a review article conducted to examine the effect of androgens on sexual function in post-menopausal women. In this study, the articles indexed in Pubmed, Sc...

Testicular synthesis and vitamin D action.

CONTEXT The vitamin D system has pleiotropic effects not only in bone metabolism. Its role in testicular steroidogenesis is new and deserves intensive research. OBJECTIVE We hypothesize that vitamin D, especially 1,25 dihydroxyvitamin D3 [1,25(OH)2D3 (calcitriol)] induces male steroidogenesis and intend to identify its impact on genes and pathways in testicular androgen regulation. METHODS ...

Involvement of inducible nitric oxide synthase in stress-impaired testicular steroidogenesis.

The immobilization stress induces an acute inhibition of testicular steroidogenesis that is mediated by the nitric oxide (NO) signaling pathway. Here we compared the effects of 2-h immobilization stress on in vivo and in vitro rat steroidogenesis at two time points, 0 h and 6 h after the end of the stress session. As expected, serum androgens and human chorionic gonadotropin (hCG)-stimulated pr...